Urgent! Computer poisoning it!

My super-slow-speed Internet access computer, open a web page on the old Screen of Death.And the old home page was changed to:www.3929.cn?tn=10279, seeking solutions.

of the system must be re-formatted to modify the basic antivirus 360 IE can not repair or restoration of Kaspersky Anti-Virus IE with the poisoning.
IE7, you can reset IE .Tools-internet options – High – reset.
With 360 security guardian repair IE.Antivirus computer in Safe Mode